Microphthalmia-associated Transcription Factor Regulates RAB27A Gene Expression and Controls Melanosome Transport
نویسندگان
چکیده
منابع مشابه
Rab27a: A Key to Melanosome Transport in Human Melanocytes
Normal pigmentation depends on the uniform distribution of melanin-containing vesicles, the melanosomes, in the epidermis. Griscelli syndrome (GS) is a rare autosomal recessive disease, characterized by an immune deficiency and a partial albinism that has been ascribed to an abnormal melanosome distribution. GS maps to 15q21 and was first associated with mutations in the myosin-V gene. However,...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.m800130200